AI hype has reached fever pitch, but most startups won’t survive the transition from demos to durable businesses.
This cohort cuts through the noise to spotlight 45 companies we expect to have an outsized, lasting impact over the next 5-10 years — from AI infrastructure that powers autonomous enterprise systems to vertical AI applications in healthcare, financial services, and manufacturing that solve operational problems.
Using CB Insights’ proprietary data — including Commercial Maturity, Mosaic, patents, business relationships, and funding — we identified 45 emerging players most likely to have a strong exit in the next 5-10 years.
Key takeaways
- Agent infrastructure is the new frontier. The cohort reveals a decisive bet on agentic AI, with startups like Coval (AI agent testing), Questflow (multi-agent orchestration), and Syncari (agentic master data management) building the foundational tools that enable autonomous AI to operate reliably at scale. These companies are positioned for outsized impact because they’re creating the critical layer to embed AI into workflows — just as cloud infrastructure enabled SaaS, agent infrastructure will enable the next wave of autonomous enterprise software.
- The 45 hotshots have collectively formed over 110 business relationships since 2024. LLM data preparation company LlamaIndex leads the pack (18 partnerships), having partnered with incumbents like Microsoft and Databricks, while blockchain infrastructure API startup Crossmint has forged partnerships with Visa (to enable AI-driven on-chain payments) and Moneygram (to power new stablecoin cross-border payment experience). As these startups scale over the next 5–10 years, this early validation with enterprise incumbents will become harder to displace as customers build workflows around their products.
- Industrial AI is the most promising area, with companies in this space having experienced the highest Mosaic score increase over the last 6 months. This includes GIS platform Felt (+71 points in 6 months) and humanoid developer Persona AI (+57). This momentum reflects investor and customer recognition that industrial AI creates defensible moats through domain-specific datasets that take years to build. Unlike horizontal tools, this vertical expertise can’t be easily replicated, positioning these companies as prime acquisition targets for industrial incumbents seeking AI capabilities over the next 5-10 years.
- Elite management teams cluster in enterprise infrastructure. Top Management Mosaic scores concentrate in enterprise tech, with Lineaje (962/1000; software supply chain security platform), Maven AGI (956/1000; customer service AI agents), ProRata.ai (950/1000; AI-powered search and advertising), and Harmonic (876/1000; mathematical superintelligence) all led by executives hailing from incumbents like Google, Robinhood, and Stripe. These companies signal that the most experienced founders see enterprise infrastructure — not verticalized or consumer AI — as the category where technical depth and execution create the most competitive advantage.
Methodology
We used CB Insights data to analyze hundreds of VC-backed private tech companies with Mosaic scores of 600+ and an early commercial maturity score.
Our scoring model factors in signals like investor quality, business relationships, Mosaic scores, key people data, and patents. We excluded companies with fewer than 100 employees. Data is as of 9/29/2025.
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