
Orna Therapeutics
Founded Year
2019Stage
Series B | AliveTotal Raised
$321MValuation
$0000Last Raised
$221M | 3 yrs agoRevenue
$0000Mosaic Score The Mosaic Score is an algorithm that measures the overall financial health and market potential of private companies.
-11 points in the past 30 days
About Orna Therapeutics
Orna Therapeutics is a biotechnology company involved in the development of circular RNA therapeutics and lipid nanoparticle (LNP) delivery systems. The company's offerings include engineered circular RNA (oRNA) medicines meant to treat various diseases and LNP technologies that deliver these RNA therapies to targeted sites in the body. Orna Therapeutics serves sectors related to oncology, autoimmune disease treatment, and genetic disorders. It was founded in 2019 and is based in Cambridge, Massachusetts.
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Expert Collections containing Orna Therapeutics
Expert Collections are analyst-curated lists that highlight the companies you need to know in the most important technology spaces.
Orna Therapeutics is included in 1 Expert Collection, including Unicorns- Billion Dollar Startups.
Unicorns- Billion Dollar Startups
1,309 items
Orna Therapeutics Patents
Orna Therapeutics has filed 17 patents.
The 3 most popular patent topics include:
- molecular biology
- rna
- biotechnology

Application Date | Grant Date | Title | Related Topics | Status |
|---|---|---|---|---|
11/3/2023 | 12/31/2024 | Molecular biology, RNA, Biotechnology, Gene expression, Genetics | Grant |
Application Date | 11/3/2023 |
|---|---|
Grant Date | 12/31/2024 |
Title | |
Related Topics | Molecular biology, RNA, Biotechnology, Gene expression, Genetics |
Status | Grant |
Latest Orna Therapeutics News
Oct 24, 2025
News provided by Share this article Share toX WATERTOWN, Mass., Oct. 24, 2025 /PRNewswire/ -- Orna Therapeutics, a leading biotechnology company developing a proprietary pipeline of in vivo therapies across a broad range of autoimmune and oncology indications, today announced an upcoming presentation at the American College of Rheumatology (ACR) Annual Meeting being held October 24-29, 2025, in Chicago, Illinois. This dataset is a broader update on Orna's lead program, ORN-252, as it continues toward clinical entry in the first half of 2026. Presentation Details (encore): Speaker: Isin Dalkilic-Liddle, Ph.D., Vice President, Head of Discovery Sciences, Orna Therapeutics Date/Time: Monday, October 27, 2025, 10:30 AM – 12:30 PM CDT Session Name: (0934-0954) Systemic Lupus Erythematosus – Animal Models Poster Location: Hall F1 About Orna Therapeutics Orna Therapeutics is dedicated to designing and delivering a new class of fully engineered circular RNA (oRNA®) therapeutics to unlock the potential of RNA medicine to treat diseases anywhere in the body. Orna's oRNA transcripts have advantages over traditional mRNA approaches, including simplified production, improved formulation into lipid nanoparticles, and superior protein expression. Its industry-leading LNP-based delivery systems and comprehensive editing programs position Orna to advance novel RNA medicines with vast potential to transform patient care. To learn more, visit www.ornatx.com and follow Orna Therapeutics on X and LinkedIn . Orna Therapeutics Investor Contact:
Orna Therapeutics Frequently Asked Questions (FAQ)
When was Orna Therapeutics founded?
Orna Therapeutics was founded in 2019.
Where is Orna Therapeutics's headquarters?
Orna Therapeutics's headquarters is located at 620 Memorial Drive, Cambridge.
What is Orna Therapeutics's latest funding round?
Orna Therapeutics's latest funding round is Series B.
How much did Orna Therapeutics raise?
Orna Therapeutics raised a total of $321M.
Who are the investors of Orna Therapeutics?
Investors of Orna Therapeutics include Merck, MPM BioImpact, Kite Pharma, Pagsgroup, Astellas Venture Management and 6 more.
Who are Orna Therapeutics's competitors?
Competitors of Orna Therapeutics include Avidity Biosciences, CircNova, Strand Therapeutics, Harness Therapeutics, Laronde and 7 more.
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Compare Orna Therapeutics to Competitors

Strand Therapeutics focuses on the development of programmable, long-acting mRNA therapeutics within the biotechnology sector. The company offers a platform for creating mRNA drugs that are designed to deliver precise, multi-functional, and potentially curative treatments by programming logic-based circuits into mRNA to control protein expression in targeted cells. Strand Therapeutics' products are primarily aimed at improving treatment options for cancer and other life-threatening diseases. It was founded in 2017 and is based in Boston, Massachusetts.

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Versameb focuses on the discovery and development of ribonucleic acid (RNA) based drugs. The company provides solutions for modulating protein expression and influencing therapeutic targets using a molecular construct. Versameb's VERSagile technology platform supports the application of functional RNA in different disease contexts to expand the use of RNA therapeutics. It was founded in 2017 and is based in Basel, Switzerland.
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Sapreme Technologies is a preclinical-stage biotech company focused on developing RNA therapeutics for genetically driven diseases. The company's main offerings include endosomal escape technology that facilitates the delivery of large molecules such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) to intracellular targets in various tissues, including the liver, muscle, heart, kidney, and brain. Sapreme's technology platform aims to improve receptor-targeted delivery and endosomal release of therapeutics in conditions like neuromuscular, renal, and cardiometabolic diseases. It was founded in 2016 and is based in Utrecht, Netherlands.
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